GAMBARAN PLATELET TO LYMPHOCYTE RATIO (PLR) SESUDAH KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA

Maharani, Abelyna Sri (2026) GAMBARAN PLATELET TO LYMPHOCYTE RATIO (PLR) SESUDAH KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2026.

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Abstract

DESCRIPTION OF PLATELET TO LYMPHOCYTE RATIO (PLR) AFTER CHEMOTHERAPY IN BREAST CANCER PATIENTS AT BALI MANDARA REGIONAL GENERAL HOSPITAL ABSTRACT Background: Breast cancer, with the highest number of cases in Indonesia, requires chemotherapy which can trigger systemic inflammation. The Platelet-to Lymphocyte Ratio (PLR) serves as a vital indicator for monitoring the balance of immune response and inflammation in patients post chemotherapy. Objective: The purpose of this study was to describe the Platelet to Lymphocyte Ratio (PLR) after chemotherapy in breast cancer patients at Bali Mandara Regional General Hospital. Methods: This descriptive study used secondary data from medical records in 2025 with a total sampling technique of 165 respondents, analyzed to describe characteristics and PLR values based on a threshold of 150. Results: Most respondents were in the pre-elderly age group (45-59 years) at 59.4%, the histopathological type was dominated by Invasive carcinoma of no special type at 78.8%, and the majority were Grade 2 malignancy at 52.1%. Examination results showed that most respondents had a high category PLR value (≥150) with 119 people (72.1%), while the low category (<150) consisted of 46 people (27.9%). The highest distribution of high PLR values was found in the pre-elderly age group (43.6%), Invasive carcinoma of no special type (57.6%), and Grade 2 (37.0%). Conclusion: The majority of breast cancer patients after chemotherapy at Bali Mandara Regional General Hospital had high PLR values (≥150). These findings illustrate a dominant systemic inflammatory condition in patients after chemotherapy, particularly in the pre-elderly age group with moderate malignancy grade. Keywords: breast cancer, chemotherapy, platelet to lymphocyte ratio (PLR). GAMBARAN PLATELET TO LYMPHOCYTE RATIO (PLR) SESUDAH KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA ABSTRAK Latar belakang: Kanker payudara dengan kasus tertinggi di Indonesia memerlukan kemoterapi yang dapat memicu inflamasi sistemik. Platelet-to Lymphocyte Ratio (PLR) menjadi indikator penting pemantauan keseimbangan respon imun dan inflamasi pasien sesudah kemoterapi. Tujuan: Tujuan penelitian ini untuk mengetahui gambaran Platelet to Lymphocyte Ratio (PLR) sesudah kemoterapi pada pasien kanker payudara di RSUD Bali Mandara. Metode: Penelitian deskriptif ini menggunakan data sekunder rekam medis tahun 2025 dengan teknik total sampling terhadap 165 responden, yang dianalisis untuk menggambarkan karakteristik serta nilai PLR berdasarkan ambang batas 150. Hasil: Karakteristik responden mayoritas berada pada kelompok usia pra-lanjut usia (45-59 tahun) sebanyak 59,4%, tipe histopatologi didominasi Invasive carcinoma of no special type sebanyak 78,8%, dan derajat keganasan mayoritas Grade 2 sebanyak 52,1%. Hasil pemeriksaan menunjukkan sebagian besar responden memiliki nilai PLR kategori tinggi (≥150) yaitu sebanyak 119 orang (72,1%), sedangkan kategori rendah (<150) sebanyak 46 orang (27,9%). Distribusi nilai PLR tinggi paling banyak ditemukan pada kelompok usia pra-lanjut usia (43,6%), tipe kanker Invasive carcinoma of no special type (57,6%), dan Grade 2 (37,0%). Kesimpulan: Pasien kanker payudara sesudah kemoterapi di RSUD Bali Mandara mayoritas memiliki nilai PLR yang tinggi (≥150). Temuan ini menggambarkan adanya kondisi inflamasi sistemik yang dominan pada pasien sesudah kemoterapi, terutama pada kelompok usia pra-lanjut usia dengan derajat keganasan sedang. Kata kunci : kanker payudara, kemoterapi, platelet to lymphocyte ratio (PLR).

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