HUBUNGAN FREKUENSI KEMOTERAPI DENGAN LYMPHOCYTE TO MONOCYTE RATIO (LMR) PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA

Pradnyaswari, Anak Agung Ari Adristi (2026) HUBUNGAN FREKUENSI KEMOTERAPI DENGAN LYMPHOCYTE TO MONOCYTE RATIO (LMR) PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2026.

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Abstract

HUBUNGAN FREKUENSI KEMOTERAPI DENGAN LYMPHOCYTE TO MONOCYTE RATIO (LMR) PADA PASIEN KANKER PAYUDARA DI RSUD BALI MANDARA ABSTRAK Latar Belakang: Kanker payudara merupakan salah satu kanker yang paling sering terjadi pada wanita. Kemoterapi sebagai terapi sistemik dapat memengaruhi komponen darah tepi, termasuk limfosit dan monosit, yang kemudian dapat tercermin pada nilai Lymphocyte to Monocyte Ratio (LMR). Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan frekuensi kemoterapi dengan Lymphocyte to Monocyte Ratio (LMR) pada pasien kanker payudara di RSUD Bali Mandara. Metode: Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross sectional. Sampel berjumlah 30 pasien kanker payudara pascakamoterapi yang dipilih dengan teknik consecutive sampling. Data frekuensi kemoterapi diperoleh dari rekam medis, sedangkan data limfosit dan monosit diperoleh melalui pemeriksaan darah lengkap menggunakan hematology analyzer, kemudian dihitung nilai LMR. Hasil: Sebagian besar subjek berada pada usia lansia awal (57%), seluruh subjek berjenis kelamin perempuan, frekuensi kemoterapi menunjukkan proporsi yang sama antara kelompok frekuensi rendah dan tinggi, limfosit normal 53%, monosit normal 97%, dan LMR normal 80%. Hasil uji Spearman Rank menunjukkan r = -0,214 dengan p = 0,257 (p > 0,05). Simpulan: Tidak terdapat hubungan yang bermakna secara statistik antara frekuensi kemoterapi dengan nilai LMR pada pasien kanker payudara di RSUD Bali Mandara. Kata Kunci: kemoterapi, limfosit, monosit, LMR, kanker payudara THE RELATIONSHIP BETWEEN CHEMOTHERAPY FREQUENCY AND LYMPHOCYTE TO MONOCYTE RATIO (LMR) IN BREAST CANCER PATIENTS AT RSUD BALI MANDARA ABSTRACT Background: Breast cancer is one of the most common cancers in women. Chemotherapy as a systemic therapy may affect peripheral blood components, including lymphocytes and monocytes, which can be reflected in the Lymphocyte to Monocyte Ratio (LMR). Objective: This study aimed to determine the relationship between chemotherapy frequency and the Lymphocyte to Monocyte Ratio (LMR) in breast cancer patients at RSUD Bali Mandara. Methods: This study used an observational analytic design with a cross-sectional approach. The sample consisted of 30 post-chemotherapy breast cancer patients selected using a consecutive sampling technique. Data on chemotherapy frequency were obtained from medical records, while lymphocyte and monocyte values were obtained through complete blood count examination using a hematology analyzer, and the LMR was then calculated. Results: Most subjects were early elderly (57%), all subjects were female, chemotherapy frequency showed equal proportions between the low and high-frequency group, normal lymphocyte levels were found in 53%, normal monocyte levels in 97%, and normal LMR values in 80% of subjects. The Spearman Rank test showed rs = -0.214 with p = 0.257 (p > 0.05). Conclusion: There was no statistically significant relationship between chemotherapy frequency and LMR values in breast cancer patients at RSUD Bali Mandara. Keywords: chemotherapy, lymphocyte, monocyte, LMR, breast cancer

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