HUBUNGAN KADAR HbA1c DENGAN KREATININ SERUM PADA PENDERITA DIABETES MELITUS TIPE 2 DI RSUD SANJIWANI GIANYAR

Wedayanti, Ni Luh Komang (2026) HUBUNGAN KADAR HbA1c DENGAN KREATININ SERUM PADA PENDERITA DIABETES MELITUS TIPE 2 DI RSUD SANJIWANI GIANYAR. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2026.

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Abstract

CORRELATION BETWEEN HbA1c AND SERUM CREATININE LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT SANJIWANI REGIONAL GENERAL HOSPITAL GIANYAR ABSTRACT Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that may lead to various complications, including impaired kidney function. Glycated hemoglobin (HbA1c) is used to assess long-term glycemic control, while serum creatinine is a marker of kidney function. This study aimed to determine the relationship between HbA1c and serum creatinine levels in patients with T2DM at Sanjiwani Gianyar Regional Hospital. An observational analytic study with a cross-sectional design was conducted using medical record data. A total of 144 patients with T2DM who met the eligibility criteria were included. The relationship between variables was analyzed using Spearman's rho correlation test. The results showed that 74.3% of subjects had uncontrolled HbA1c levels, with a mean of 8.69%, while 46.5% had normal serum creatinine levels, with a mean of 1.20 mg/dL. Spearman's rho analysis demonstrated a significant positive correlation between HbA1c and serum creatinine levels (p<0.001; r=0.356). In conclusion, higher HbA1c levels tended to be associated with higher serum creatinine levels. However, the weak correlation indicates that variations in serum creatinine are not solely associated with HbA1c levels but may also be influenced by other factors beyond the scope of this study, as well as the limited ability of serum creatinine to detect early kidney impairment. Keywords: HbA1c, Serum Creatinine HUBUNGAN KADAR HbA1c DENGAN KREATININ SERUM PADA PENDERITA DIABETES MELITUS TIPE 2 DI RSUD SANJIWANI GIANYAR ABSTRAK Diabetes melitus (DM) tipe 2 merupakan penyakit metabolik kronis yang dapat menyebabkan berbagai komplikasi, termasuk gangguan fungsi ginjal. Hemoglobin terglikasi (HbA1c) digunakan untuk menilai kontrol glikemik jangka panjang, sedangkan kreatinin serum merupakan indikator fungsi ginjal. Penelitian ini bertujuan mengetahui hubungan kadar HbA1c dengan kreatinin serum pada penderita DM tipe 2 di RSUD Sanjiwani Gianyar. Penelitian menggunakan desain analitik observasional dengan pendekatan cross-sectional berdasarkan data rekam medis. Sampel penelitian berjumlah 144 penderita DM tipe 2 yang memenuhi kriteria penelitian. Analisis hubungan dilakukan menggunakan uji korelasi Spearman rho. Hasil penelitian menunjukkan 74,3% subyek memiliki kadar HbA1c tidak terkontrol dengan rata-rata 8,69%, sedangkan 46,5% memiliki kadar kreatinin serum normal dengan rata-rata 1,20 mg/dL. Uji Spearman rho menunjukkan terdapat hubungan positif yang bermakna antara kadar HbA1c dan kreatinin serum (p<0,001; r=0,356). Simpulan penelitian ini menunjukkan bahwa semakin tinggi kadar HbA1c cenderung diikuti peningkatan kadar kreatinin serum. Namun, kekuatan hubungan yang lemah menunjukkan bahwa variasi kadar kreatinin serum tidak hanya berkaitan dengan kadar HbA1c, tetapi juga dipengaruhi oleh faktor lain di luar penelitian serta keterbatasan kreatinin serum dalam mendeteksi gangguan fungsi ginjal pada tahap awal. Kata kunci: HbA1c, Kreatinin Serum

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