ANALISIS NILAI PROTHROMBIN TIME DARAH SITRAT ANTARA PEMERIKSAAN SEGERA DAN WAKTU PENUNDAAN PADA SUHU DINGIN

Pebriyanti, Ni Made Vevi (2026) ANALISIS NILAI PROTHROMBIN TIME DARAH SITRAT ANTARA PEMERIKSAAN SEGERA DAN WAKTU PENUNDAAN PADA SUHU DINGIN. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2026.

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Abstract

ANALYSIS OF PROTHROMBIN TIME VALUES OF CITRATE BLOOD BETWEEN IMMEDIATE AND DELAYED TIME EXAMINATION AT COLD TEMPERATURES Background: Prothrombin Time (PT) is a hemostatic parameter used to evaluate the extrinsic pathway of blood coagulation. PT results are influenced by pre-analytical factors, one of which is delayed examination. Objective: This study aimed to analyze PT values in citrated blood between immediate examination and delayed examination at cold temperature. Methods: This study employed a quasi-experimental design using a repeated-measures approach involving 6 participants. PT examination was performed immediately and after delays of 1 hour, 2 hours, and 3 hours at ±4°C. Data were analyzed using repeated measures ANOVA followed by the Bonferroni test. Results: The mean PT values in the immediate examination and 1-hour delay were 10.4 seconds, while the 2-hour and 3-hour delays were 10.6 seconds and 10.7 seconds, respectively. Repeated measures ANOVA showed a significant overall difference (p=0.004), while the Bonferroni test showed a significant difference only between the 1-hour and 3-hour delays (p=0.018). PT values tended to increase with increasing examination delay time. Conclusion: Significant differences in PT values were observed between immediate and delayed examinations at cold temperature (±4°C). However, delays of up to 2 hours still yielded relatively stable PT results compared with immediate examination. Keywords: Prothrombin Time, delay, cold temperature ANALISIS NILAI PROTHROMBIN TIME DARAH SITRAT ANTARA PEMERIKSAAN SEGERA DAN WAKTU PENUNDAAN PADA SUHU DINGIN Latar belakang: Prothrombin Time (PT) merupakan parameter hemostasis untuk mengevaluasi jalur ekstrinsik pembekuan darah. Hasil PT dipengaruhi faktor pra-analitik, salah satunya penundaan pemeriksaan. Tujuan: Menganalisis nilai PT pada darah sitrat antara pemeriksaan segera dan penundaan pada suhu dingin (±4°C). Metode: Penelitian menggunakan desain quasi-experimental dengan pendekatan repeated measures pada 6 responden. Pemeriksaan PT dilakukan segera serta setelah penundaan 1 jam, 2 jam, dan 3 jam pada suhu ±4°C. Data dianalisis menggunakan repeated measures ANOVA dan uji Bonferroni. Hasil: Rerata nilai PT pada pemeriksaan segera dan penundaan 1 jam sebesar 10,4 detik, penundaan 2 jam 10,6 detik, dan penundaan 3 jam 10,7 detik. Hasil repeated measures ANOVA menunjukkan perbedaan bermakna secara keseluruhan (p=0,004), sedangkan uji Bonferroni menunjukkan perbedaan signifikan hanya antara penundaan 1 jam dan 3 jam (p=0,018). Nilai PT menunjukkan kecenderungan meningkat seiring bertambahnya waktu penundaan pemeriksaan. Kesimpulan: Terdapat perbedaan nilai PT antara pemeriksaan segera dan penundaan pada suhu dingin (±4°C). Meskipun demikian, penundaan hingga 2 jam masih menunjukkan hasil yang relatif stabil dibandingkan pemeriksaan segera. Kata kunci: Prothrombin Time, penundaan, suhu dingin

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