HUBUNGAN UKURAN NODUL TIROID DENGAN KADAR THYROID STIMULATING HORMONE (TSH) DAN HASIL FINE NEEDLE ASPIRATION BIOPSY (FNAB) DI RSUD BALI MANDARA

Carolina, Carin Indhita (2026) HUBUNGAN UKURAN NODUL TIROID DENGAN KADAR THYROID STIMULATING HORMONE (TSH) DAN HASIL FINE NEEDLE ASPIRATION BIOPSY (FNAB) DI RSUD BALI MANDARA. Diploma thesis, PoltekkesKemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2026.

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Abstract

THE RELATIONSHIP OF THYROID NODULE SIZE WITH THYROID STIMULATING HORMONE (TSH) LEVELS AND FINE NEEDLE ASPIRATION BIOPSY (FNAB) RESULTS AT BALI MANDARA GENERAL HOSPITAL ABSTRACT Background: Thyroid cancer is one of the endocrine malignancies with an increasing incidence worldwide and in Indonesia. Thyroid cancer generally originates from thyroid nodules that require further evaluation to determine the risk of malignancy. Ultrasonography (USG), Thyroid Stimulating Hormone (TSH) measurement, and Fine Needle Aspiration Biopsy (FNAB) are commonly used in the assessment of thyroid nodules. At Bali Mandara General Hospital, the number of patients with thyroid nodules increased from 65 in 2022 to 460 in 2025, accompanied by an increase in new thyroid cancer cases from 11 to 59. Objective: To determine the relationship between thyroid nodule size, TSH levels, and FNAB results among patients with thyroid nodules at Bali Mandara General Hospital. Methods: This quantitative study employed a retrospective cross-sectional design using secondary data obtained from the medical records of 240 patients who met the inclusion and exclusion criteria. Data were analyzed using the Chi-square test and Fisher’s Exact test with a significance level of p<0.05. Results: Most patients had medium-sized thyroid nodules (2–4 cm) (68.3%), normal TSH levels (79.6%), and benign FNAB results (66.7%). A significant association was found between thyroid nodule size and TSH levels (p=0.003). However, no significant association was observed between thyroid nodule size and FNAB results (p=0.088). Conclusion: Thyroid nodule size was associated with TSH levels but not with FNAB results. Comprehensive evaluation of thyroid nodules through clinical examination, laboratory testing, ultrasonography, and FNAB remains essential. Keywords: thyroid, nodule size, TSH, FNAB HUBUNGAN UKURAN NODUL TIROID DENGAN KADAR THYROID STIMULATING HORMONE (TSH) DAN HASIL FINE NEEDLE ASPIRATION BIOPSY (FNAB) DI RSUD BALI MANDARA ABSTRAK Latar Belakang: Kanker tiroid merupakan salah satu keganasan endokrin dengan angka kejadian yang terus meningkat secara global maupun di Indonesia. Kanker tiroid umumnya berawal dari nodul tiroid yang memerlukan evaluasi untuk menentukan risiko keganasan. Pemeriksaan ultrasonografi (USG), kadar Thyroid Stimulating Hormone (TSH), dan Fine Needle Aspiration Biopsy (FNAB) sering digunakan dalam penilaian nodul tiroid. Di RSUD Bali Mandara, jumlah pasien nodul tiroid meningkat dari 65 pasien pada tahun 2022 menjadi 460 pasien pada tahun 2025, disertai peningkatan kasus baru kanker tiroid dari 11 menjadi 59 kasus. Tujuan: Mengetahui hubungan antara ukuran nodul tiroid dengan kadar TSH dan hasil FNAB pada pasien nodul tiroid di RSUD Bali Mandara. Metode: Penelitian kuantitatif dengan desain cross-sectional retrospektif menggunakan data sekunder rekam medis 240 pasien yang memenuhi kriteria inklusi dan eksklusi. Data dianalisis menggunakan uji Chi-square dan Fisher Exact dengan tingkat kemaknaan p<0,05. Hasil: Sebagian besar pasien memiliki ukuran nodul sedang (2–4 cm) sebesar 68,3%, kadar TSH normal 79,6%, dan hasil FNAB jinak 66,7%. Terdapat hubungan bermakna antara ukuran nodul tiroid dan kadar TSH (p=0,003). Sebaliknya, tidak terdapat hubungan bermakna antara ukuran nodul tiroid dan hasil FNAB (p=0,088). Simpulan: Ukuran nodul tiroid berhubungan dengan kadar TSH, tetapi tidak berhubungan dengan hasil FNAB. Evaluasi nodul tiroid perlu dilakukan secara komprehensif melalui pemeriksaan klinis, laboratorium, ultrasonografi, dan FNAB. Kata kunci: tiroid, ukuran nodul, TSH, FNAB

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