HUBUNGAN KADAR VITAMIN D SERUM DENGAN KADAR HEMOGLOBIN TERGLIKASI (HbA1c) PADA PASIEN DIABETES MELITUS DI LABORATORIUM KLINIK PRODIA DENPASAR

Devi Tresna Anjani, Putu (2026) HUBUNGAN KADAR VITAMIN D SERUM DENGAN KADAR HEMOGLOBIN TERGLIKASI (HbA1c) PADA PASIEN DIABETES MELITUS DI LABORATORIUM KLINIK PRODIA DENPASAR. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis.

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Abstract

The Relationship Between Serum Vitamin D Levels and Glycated Hemoglobin (HbA1c) Levels in Patients with Diabetes Mellitus at Prodia Clinical Laboratory Denpasar ABSTRACT Background: Vitamin D plays an essential role in glucose metabolism, insulin sensitivity, and β-cell function. Vitamin D deficiency is suspected to be associated with increased HbA1c levels in diabetic patients. Objective: To determine the relationship between serum vitamin D levels and HbA1c levels among patients with diabetes mellitus at Prodia Clinical Laboratory Denpasar. Methods: This observational analytic study used a cross-sectional design. A total of 215 respondents were selected through accidental sampling based on medical record data. Vitamin D status was categorized as deficiency, insufficiency, or sufficiency. Glycemic control was assessed using HbA1c categories. Normality was tested with Kolmogorov–Smirnov, and the relationship between variables was analyzed using Spearman Rank correlation. Results: Most respondents had insufficient vitamin D levels (43.3%), followed by sufficient (36.7%) and deficient (20%). A majority (84.7%) achieved good HbA1c control. Spearman analysis showed a significant negative correlation between serum vitamin D and HbA1c (r = -0.337; p = 0.000). Conclusion: There is a significant negative relationship between serum vitamin D levels and HbA1c. Lower vitamin D levels are associated with higher HbA1c values. Keywords: Serum vitamin D, HbA1c, diabetes mellitus, glycemic control. Hubungan Kadar Vitamin D Serum dengan Kadar Hemoglobin Terglikasi (HbA1c) pada pasien Diabetes Melitus di Laboratorium Klinik Prodia Denpasar ABSTRAK Latar Belakang: Vitamin D memiliki peran penting dalam metabolisme glukosa, sensitivitas insulin, dan regulasi fungsi sel β pankreas. Ketidakseimbangan kadar vitamin D diduga berhubungan dengan peningkatan kadar HbA1c pada pasien diabetes melitus. Tujuan: Mengetahui hubungan antara kadar vitamin D serum dengan kadar HbA1c pada pasien diabetes melitus di Laboratorium Klinik Prodia Denpasar. Metode: Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional. Sampel terdiri dari 215 responden yang diambil secara accidental sampling berdasarkan data rekam medis. Kadar vitamin D dikategorikan menjadi defisiensi, insufisiensi, dan sufisiensi. Kontrol glikemik dinilai melalui kategori HbA1c. Uji normalitas menggunakan Kolmogorov–Smirnov dan analisis hubungan menggunakan korelasi Rank-Spearman. Hasil: Mayoritas responden memiliki status vitamin D insufisiensi (43,3%), diikuti sufisiensi (36,7%) dan defisiensi (20%). Sebagian besar responden memiliki kadar HbA1c terkontrol baik (84,7%). Hasil uji Spearman menunjukkan hubungan negatif signifikan antara kadar vitamin D dan HbA1c (r = -0.337; p = 0.000). Kesimpulan: Terdapat hubungan negatif yang signifikan antara kadar vitamin D dan kadar HbA1c. Semakin rendah kadar vitamin D serum, semakin tinggi kadar HbA1c. Kata Kunci: Vitamin D serum, HbA1c, diabetes melitus, kontrol glikemik

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