HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA DIABETES MELITUS DI RUMAH SAKIT DAERAH MANGUSADA

Devi, Komang Ayu Aishvarya Gangga (2025) HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA DIABETES MELITUS DI RUMAH SAKIT DAERAH MANGUSADA. Diploma thesis, Poltekkes Kemenkes Denpasar Jurusan Teknologi Laboratorium Medis 2025.

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Abstract

THE RELATIONSHIP BETWEEN FASTING BLOOD GLUCOSE LEVELS AND C-REACTIVE PROTEIN LEVELS AMONG DIABETES MELLITUS PATIENTS AT RUMAH SAKIT DAERAH MANGUSADA ABSTRACT Background: Diabetes mellitus (DM) is characterized by elevated blood glucose levels resulting from decreased insulin secretion by pancreatic beta cells. Fasting blood glucose (FBG) measurement is commonly used to monitor DM, requiring patients to fast for a minimum of eight hours. Insufficient insulin production impairs glucose uptake into body tissues, leading to hyperglycemia. Chronic hyperglycemia subsequently stimulates the production of inflammatory cytokines, which promotes the hepatic synthesis of c-reactive protein (CRP). Aim: This study aims to determine the relationship between FBG levels and CRP levels in patients with diabetes mellitus at Rumah Sakit Daerah Mangusada. Methods: An observational analytic study with a cross-sectional design was conducted using purposive sampling, with a total sample of 25 DM patients at Rumah Sakit Daerah Mangusada. Data were analyzed using the Shapiro-Wilk test for normality and the Spearman's rank for correlation test. Result: the analysis that has been carried out on the Shapiro-Wilk, obtained a sig. (2 tailed) 0.012 which means 0.012 < 0.05 and correlation coefficient is 0.493. Conclusion: it can be concluded that has a positive relationship with a moderate correlation between blood glucose levels and CRP levels in diabetic patients at Rumah Sakit Daerah Mangusada. Keyword: C-Reactive Protein; Blood Glucose HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA DIABETES MELITUS DI RUMAH SAKIT DAERAH MANGUSADA ABSTRAK Latar Belakang: Diabetes melitus (DM) ditandai dengan peningkatan kadar gula darah akibat berkurangnya sekresi insulin oleh sel beta pankreas. Gula darah puasa (GDP) digunakan sebagai metode monitoring DM dengan syarat pasien berpuasa minimal delapan jam. Ketidakcukupan produksi insulin menyebabkan glukosa tidak dapat masuk ke jaringan tubuh sehingga menyebabkan hiperglikemia. Hiperglikemia kronik kemudian merangsang produksi sitokin inflamasi yang memicu peningkatan c-reactive protein (CRP) oleh hati. Tujuan: untuk mengetahui hubungan kadar GDP dengan kadar CRP pada penderita diabetes melitus di Rumah Sakit Daerah Mangusada. Metode: observasional analitik dengan pendekatan cross-sectional, teknik pengambilan sampel menggunakan metode purposive sampling dengan jumlah sampel 25 pada penderita DM di Rumah Sakit Daerah Mangusada. Data dianalisis menggunakan uji normalitas Shapiro-Wilk dan uji normalitas data menggunakan uji korelasi Rank-Spearman. Hasil: berdasarkan hasil uji korelasi Rank-Spearman didapatkan hasil sig. (2 tailed) 0.012 yang artinya 0.012 < 0.05. Simpulan: dapat disimpulkan bahwa adanya hubungan positif dengan tingkat korelasi sedang antara kadar GDP dan kadar CRP pada penderita DM di Rumah Sakit Daerah Mangusada. Kata kunci: C-Reactive Protein; Gula Darah

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